• WELCOME
  • SCIENCE & RESEARCH
  • BLOOD PRESSURE MEASUREMENT
    • History of blood pressure measurement
    • Measurement in low resource settings
    • Guidelines, standards and recommendations
    • Device validation protocols
    • Device validation studies
    • Device validation – State-of-the-market
    • Conventional blood pressure measurement
    • The mercury issue
    • ABPM – General
    • ABPM – Reference values
    • ABPM – Patterns and sub-groups
    • ABPM – Nocturnal blood pressure
    • ABPM – drug assessment
    • ABPM – Elderly
    • ABPM – Pregnancy
    • ABPM – Outcome
    • ABPM – Computer analysis and indices
    • ABPM – Hypotension
    • Self-blood pressure measurement
  • DRUG TREATMENT AND TRIALS
    • General
    • EWPHE Study
    • Syst-Eur Study
    • PROGRESS Study
    • HYVET Study
    • ASCOT Study
    • REASON Study
    • Aliskiren
  • CASE REPORTS
  • COMPUTERISED MANAGEMENT OF CV DISEASE
  • GENERAL AND EDUCATIONAL
  • GENETICS
  • LITERARY AND HISTORICAL
  • BIOGRAPHY
    • Dominic Corrigan
    • Oliver Fitzgerald
    • William Stokes
    • Robert Graves
    • John Cheyne
    • Robert Adams
    • J.D.H. Widdess
    • Walter Sommerville
    • Samuel Beckett
    • A.J. (Con) Leventhal
    • Nevill Johnson
      • Nevill Johnson: Paint the smell of grass
    • Oliver St John Gogarty
    • Denis Johnston
    • Dom Peter Flood
    • Micheal MacLiammoir
    • Petr Skrabanek
  • HISTORY OF MEDICAL INSTITUTIONS
    • A Century of Service: The City of Dublin Skin and Cancer Hospital 1911-2011
    • Royal College of Surgeons in Ireland
    • Royal College of Physicians of Ireland
    • The Charitable Infirmary
    • The Richmond Hospital
    • Beaumont Hospital
  • MISCELLANEOUS ESSAYS AND LETTERS
  • MEDICAL JOURNALISM
  • MEDICAL HISTORICAL EXHIBITIONS
  • PUBLISHING
  • HUMANITARIAN ACTIVITIES
  • COMMUNICATIONS AND PRESENTATIONS
    • Scientific Presentations 1981 – 2006
    • Literary Presentations and Exhibitions
    • Humanitarian Presentations & Exhibitions
    • Communications on Medical History
  • TELEVISION AND RADIO
    • Medical Presenataions on Radio and Television
    • Historical/Literary Presentations on Radio and Television
  • CAREER OVERVIEW
    • Appointments
    • Learned Societies, Committee Membership, and Editorial Boards
    • Blood Pressue Unit and ADAPT Centre Annual Reports 1996 – 2006
  • SCIENTIFIC BIBLIOGRAPHY
    • Publications 1968 – 1979
    • Publications 1980 – 1989
    • Publications 1990 – 1999
    • Publications 2000 – 2009
    • Publications 2010 – 2016
Eoin O'Brien

ABPM – drug assessment

ABPM and drugs

Brennan M, O’Malley K, O’Brien E. The contribution of non-invasive ambulatory blood pressure measurement in antihypertensive drug evaluation. In: ISAM 1985, Proceedings of the Fifth International Symposium of Ambulatory Monitoring Eds; C. Dal Palu and A.C. Pessina. Cleup Editore. Italy. 1986. pp.255-263.

O’Brien E, Cox J. O’Malley K. Editorial Review: Ambulatory blood pressure measurement in the evaluation of blood pressure lowering drugs. J Hypertens 1989;7:243-247.

McCormack PME, Cox JP, Marron J, Mee F, Atkins N, O’Brien E, O’Malley K. The antihypertensive efficacy of ketansarin in the elderly evaluated by ambulatory blood pressure measurement. J Human Hypertens 1990;4:565-570.

Fitzgerald DJ, O’Malley K, O’Brien E. Disparity between Clinic (CBP) and Ambulatory Blood Pressure (ABP) in response to Antihypertensive Therapy. Clin Pharmacol Ther 1984;35:240.

O’Brien E, O’Malley K, Cox J, Stanton A. Ambulatory blood pressure monitoring in the evaluation of drug efficacy. Am Heart J 1991;121:999-1006

O’Brien E, O’Malley K. Ambulatory blood pressure measurements: Therapeutic implications. Arch Mal Coeur 1991;84(III):29-32

O’Brien E, O’Malley K. Importancia del control de 24 horas ambulatorio del la presion arterial en la seleccion y seguimento del tratamiento antihipertensivo. Hypertension 1991;8(suppl 2):5-10.

Stanton A, O’Brien E, Cox J, O’Brien E. The importance of 24-hour blood pressure in evaluating antihypertensive drug efficacy. J Ir Coll Physicians Surg 1992;21:111-116

Staessen J, Thijs L, Parati GF, Mancia G, O’Brien E, Clinical trials with ambulatory blood pressure monitoring: fewer patients needed? Lancet 1994;344 :1552-1556

Staessen JA, Thijs L, Bieniaszewski L, O’Brien E, Palatini P, Davidson C, Dobovisek J, Jaaskvi M, Laks T, Lehtonen A, Vanhanen H, Webster J, Fagard R. Ambulatory Monitoring Uncorrected for Placebo Overestimates Long-term Antihypertensive Action. Hypertension 1996;27[Part 1] :414-420

Fagard RH, Staessen JA, Thijs L, Gasowski J, Bulpitt CJ, Clement D, de Leeuw PW, Dobovisek J, Jaaskivi M, Leonetti G, O’Brien E, Palatini P, Parati G, Rodicio J, Vanhanen H, Webster J. Response to Antihypertensive Therapy in Older Patients With Sustained and Nonsustained Systolic Hypertension. Circulation 2000;102:1139-1144.

MaIlion J-M, Chamontin B, Asmar R, De Leeuw PW, O’Brien E, Fitzgerald D, Duprez D, O’Rourke MF, Rahn K-H, Romero R, Battegay E, Hitzenberger G, Safar ME on behalf of the Reason project. Twenty-Four-Hour Ambulatory Blood Pressure Monitoring Efficacy of Perindopril/Indapamide First-Line Combination in Hypertensive Patients. The REASON Study. Am J Hypertension 2004;17:245-251

Waeber B, O’Brien E, Camenzend E, Burnier M, Nussberger J, Cox J, Brunner H. Efficacy assessment of antihypertensive therapy. In: Ambulatory Blood Pressure. Eds: H. Brunner and B. Waeber. Raven Press. 1992.

APTH Study

Staessen J, Amery A on behalf of the Advisory Board. APTH – A trial on ambulatory blood pressure monitoring and treatment of hypertension: objectives and protocol. Acta Cardiologica 1993;48:25-42

Staessen J, Bieniaszewksi L, Buntinx F, Celis H, O’Brien ET, Van Hoof R, Fagard R. The Trough-to-Peak Ratio as an Instrument to Evaluate Antihypertensive Drugs. Hypertension 1995;26[Part I]:942-949.

Bieniaszewksi L, Staessen J, Byttebier G, De Leeuw P, Van Hedent T, Fagard R, on behalf of APTH Investigators. Trough-To-Peak Versus Surface Ratio as in the Assessment of Antihypertensive Agents. Blood Pressure 1995;4:350-357.

Staessen JA, Byttebier G, Buntinx F, Celis H, O’Brien ET, Fagard R, for the Ambulatory Blood Pressure Monitoring and Treatment of Hypertension Investigators. Antihypertensive Treatment Based on Conventional or Ambulatory Blood Pressure Measurement: A Randomized Controlled Trial. JAMA. 1997;278:1065-1072.

Celis H, Staessen JA, Thijs L, Buntinx F, De Buyzere M, Den Hond E, Fagard R, O’Brien E on behalf of the Ambulatory Blood Pressure and Treatment of Hypertension (APTH) trial investigators. Cardiovascular risk in white-coat and sustained hypertensive patients. Blood Pressure 2003;11:352-356

Den Hond E, Staessen JA on behalf of the APTH and THOP investigators. Relation between left ventricular mass and systolic blood pressure at baseline in the APTH and THOP trials. Blood Press Monit 2003, 8:173–175

OvA Study

Clement DL, [Coates A, Conway J, Mancia G, O’Brien E.] Home versus office monitoring of blood pressure: a European multicentre study of high blood pressure. J Hypertens 1989;7(suppl 3):S49-S51

Steering Committee: Clement DJ, Coats A, Conway J, Mancia G, Nielson PE, O’Brien E, Parati G, Sleght P. Office versus ambulatory recordings of blood pressure (OvA): a European multicenter study. J Hypertens 1990;8(suppl):S39-S41.

Clement DL, De Buyzere M on behalf of the OvA investigators. Office versus Ambulatory (OvA) recording of blood pressure, a European multicenter study: inclusion and early follow-up characteristics. Blood Pressure Monit 1998;3:167-172

Clement DL, De Buyzere M, De Bacquer DA, de Leeuw PW, Duprez DA, Fagard RH, Gheeraert PJ, Missault LH, Braun JJ, Six RO, Van Der Niepen P, O’Brien E for the Office versus Ambulatory Blood Pressure (OvA) Study Investigators. Prognostic Value of Ambulatory Blood-Pressure Recordings in Patients with Treated Hypertension. New Eng J Med 2003.348.207-215

.

THOP Study

Celis H, Staessen JA, Buntinx F, Fagard R, Leeman M, Thijs L, Van Hedent T, on behalf of the THOP investigators. Blood Press Monit 1998;3(suppl 1):S29-S35

Staessen JA, Celis H, Thijs L, Den Hond E, Giot C, Leeman M, O’Brien E, Vandenhoven G, Fagard R on behalf of the THOP investigators Comparison of conventional and automated blood pressure measurements: interim analysis of the THOP trial. Blood Press Monit 2002;7:61-62

Den Hond E, Celis H, Vandenhoven G, O’Brien E, Staessen JA for the THOP investigators. Determinants of white-coat syndrome assessed by ambulatory blood pressure or self-measured home blood pressure. Blood Pressure Monit 2003;8:37-40

Den Hond E, Celis H, Fagard R, Keary L, Leeman M, O’Brien E, Vandenhoven G, Staessen JA on behalf of the THOP investigators. Self-measured versus ambulatory blood pressure in the diagnosis of hypertension. J Hypertens 2003;21:1-6

Den Hond E, Staessen JA on behalf of the APTH and THOP investigators. Relation between left ventricular mass and systolic blood pressure at baseline in the APTH and THOP trials. Blood Press Monit 2003, 8:173–175

Staessen JA, Den Hond E, Celis H, Fagard R, Keary L, Vandenhoven G, O’Brien ET, for the Treatment of Hypertension Based on Home or Office Blood Pressure (THOP) Trial Investigators. Antihypertensive Treatment Based on Blood Pressure Measurement at Home or in the Physician’s Office. A Randomized Controlled Trial. JAMA 2004;291:955-964

Staessen JA, Den Hond E, Celis H, Fagard R, Keary L, Vandenhoven G, O’Brien ET, for the Treatment of Hypertension Based on Home or Office Blood Pressure (THOP) Trial Investigator. Trial finds adjusting antihypertensive drugs based on home measurement may not improve blood pressure control [Commentary by Kjeldsen SE, Reims HM, Mancia G]. Journal of Evidenced-Based Cardiovascular Medicine 2004; 8: 202-205.

Den Hond E, Staessen JA, Celis H, Fagard R, Keary L, Vandenhoven G, O’Brien ET, for the Treatment of Hypertension Based on Home or Office Blood Pressure (THOP) Trial Investigators. Antihypertensive Treatment based on Home or Office Blood Pressure – the THOP trial. Blood Press Monit 2004;9:311-314

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Pages

  • WELCOME
  • SCIENCE & RESEARCH
  • BLOOD PRESSURE MEASUREMENT
    • History of blood pressure measurement
    • Measurement in low resource settings
    • Guidelines, standards and recommendations
    • Device validation protocols
    • Device validation studies
    • Device validation – State-of-the-market
    • Conventional blood pressure measurement
    • The mercury issue
    • ABPM – General
    • ABPM – Reference values
    • ABPM – Patterns and sub-groups
    • ABPM – Nocturnal blood pressure
    • ABPM – drug assessment
    • ABPM – Elderly
    • ABPM – Pregnancy
    • ABPM – Outcome
    • ABPM – Computer analysis and indices
    • ABPM – Hypotension
    • Self-blood pressure measurement
  • DRUG TREATMENT AND TRIALS
    • General
    • EWPHE Study
    • Syst-Eur Study
    • PROGRESS Study
    • HYVET Study
    • ASCOT Study
    • REASON Study
    • Aliskiren
  • CASE REPORTS
  • COMPUTERISED MANAGEMENT OF CV DISEASE
  • GENERAL AND EDUCATIONAL
  • GENETICS
  • LITERARY AND HISTORICAL
  • BIOGRAPHY
    • Dominic Corrigan
    • Oliver Fitzgerald
    • William Stokes
    • Robert Graves
    • John Cheyne
    • Robert Adams
    • J.D.H. Widdess
    • Walter Sommerville
    • Samuel Beckett
    • A.J. (Con) Leventhal
    • Nevill Johnson
      • Nevill Johnson: Paint the smell of grass
    • Oliver St John Gogarty
    • Denis Johnston
    • Dom Peter Flood
    • Micheal MacLiammoir
    • Petr Skrabanek
  • HISTORY OF MEDICAL INSTITUTIONS
    • A Century of Service: The City of Dublin Skin and Cancer Hospital 1911-2011
    • Royal College of Surgeons in Ireland
    • Royal College of Physicians of Ireland
    • The Charitable Infirmary
    • The Richmond Hospital
    • Beaumont Hospital
  • MISCELLANEOUS ESSAYS AND LETTERS
  • MEDICAL JOURNALISM
  • MEDICAL HISTORICAL EXHIBITIONS
  • PUBLISHING
  • HUMANITARIAN ACTIVITIES
  • COMMUNICATIONS AND PRESENTATIONS
    • Scientific Presentations 1981 – 2006
    • Literary Presentations and Exhibitions
    • Humanitarian Presentations & Exhibitions
    • Communications on Medical History
  • TELEVISION AND RADIO
    • Medical Presenataions on Radio and Television
    • Historical/Literary Presentations on Radio and Television
  • CAREER OVERVIEW
    • Appointments
    • Learned Societies, Committee Membership, and Editorial Boards
    • Blood Pressue Unit and ADAPT Centre Annual Reports 1996 – 2006
  • SCIENTIFIC BIBLIOGRAPHY
    • Publications 1968 – 1979
    • Publications 1980 – 1989
    • Publications 1990 – 1999
    • Publications 2000 – 2009
    • Publications 2010 – 2016

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