• WELCOME
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  • BLOOD PRESSURE MEASUREMENT
    • History of blood pressure measurement
    • Measurement in low resource settings
    • Guidelines, standards and recommendations
    • Device validation protocols
    • Device validation studies
    • Device validation – State-of-the-market
    • Conventional blood pressure measurement
    • The mercury issue
    • ABPM – General
    • ABPM – Reference values
    • ABPM – Patterns and sub-groups
    • ABPM – Nocturnal blood pressure
    • ABPM – drug assessment
    • ABPM – Elderly
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    • Self-blood pressure measurement
  • DRUG TREATMENT AND TRIALS
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    • Nevill Johnson
      • Nevill Johnson: Paint the smell of grass
    • Oliver St John Gogarty
    • Denis Johnston
    • Dom Peter Flood
    • Micheal MacLiammoir
    • Petr Skrabanek
  • HISTORY OF MEDICAL INSTITUTIONS
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  • MISCELLANEOUS ESSAYS AND LETTERS
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  • SCIENTIFIC BIBLIOGRAPHY
    • Publications 1968 – 1979
    • Publications 1980 – 1989
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    • Publications 2010 – 2016
Eoin O'Brien

Aliskiren

Stanton A, Jensen C, Nussberger J, O’Brien E. Blood Pressure Lowereing in Essential Hypertension with an Oral Renin Inhibitor, Aliskiren. Hypertension 2003;42:1137-1143

Wood JM, Maibaum J, Rahuel J, Grütter MG, Cohen N-C, Rasetti V, Rüger H, Göschke R, Stutz S, Fuhrer W, Rigollier SP, Yamaguchi, Y, Cumin F, Baum H-P, Schnell C-R, Herold P, Mah R, Jensen C, O’Brien E, Stanton A, Bedigian MP. Structure-based design of aliskiren, a novel orally effective renin inhibitor with antihypertensive efficacy in human patients. Biochemical and Biophysical Research Communications (BBRC) 2003;308:698-705

O’Brien E. Aliskiren: a renin inhibitor offering a new approach for the treatment of hypertension. Expert Opinion on Investigational Drugs 2006;15:1269-1277

O’Brien E, Barton J, Nussberger J, Mulcahy D, Jensen C, Dicker P, Stanton A. Aliskiren provides antihypertensive efficacy and suppression of plasma rennin activity in combination with a thiazide diuretic, an angiotensin converting enzyme inhibito, or an angiotensin receptor blocker. Hypertension 2007;49:276-284

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Pages

  • WELCOME
  • SCIENCE & RESEARCH
  • BLOOD PRESSURE MEASUREMENT
    • History of blood pressure measurement
    • Measurement in low resource settings
    • Guidelines, standards and recommendations
    • Device validation protocols
    • Device validation studies
    • Device validation – State-of-the-market
    • Conventional blood pressure measurement
    • The mercury issue
    • ABPM – General
    • ABPM – Reference values
    • ABPM – Patterns and sub-groups
    • ABPM – Nocturnal blood pressure
    • ABPM – drug assessment
    • ABPM – Elderly
    • ABPM – Pregnancy
    • ABPM – Outcome
    • ABPM – Computer analysis and indices
    • ABPM – Hypotension
    • Self-blood pressure measurement
  • DRUG TREATMENT AND TRIALS
    • General
    • EWPHE Study
    • Syst-Eur Study
    • PROGRESS Study
    • HYVET Study
    • ASCOT Study
    • REASON Study
    • Aliskiren
  • CASE REPORTS
  • COMPUTERISED MANAGEMENT OF CV DISEASE
  • GENERAL AND EDUCATIONAL
  • GENETICS
  • LITERARY AND HISTORICAL
  • BIOGRAPHY
    • Dominic Corrigan
    • Oliver Fitzgerald
    • William Stokes
    • Robert Graves
    • John Cheyne
    • Robert Adams
    • J.D.H. Widdess
    • Walter Sommerville
    • Samuel Beckett
    • A.J. (Con) Leventhal
    • Nevill Johnson
      • Nevill Johnson: Paint the smell of grass
    • Oliver St John Gogarty
    • Denis Johnston
    • Dom Peter Flood
    • Micheal MacLiammoir
    • Petr Skrabanek
  • HISTORY OF MEDICAL INSTITUTIONS
    • A Century of Service: The City of Dublin Skin and Cancer Hospital 1911-2011
    • Royal College of Surgeons in Ireland
    • Royal College of Physicians of Ireland
    • The Charitable Infirmary
    • The Richmond Hospital
    • Beaumont Hospital
  • MISCELLANEOUS ESSAYS AND LETTERS
  • MEDICAL JOURNALISM
  • MEDICAL HISTORICAL EXHIBITIONS
  • PUBLISHING
  • HUMANITARIAN ACTIVITIES
  • COMMUNICATIONS AND PRESENTATIONS
    • Scientific Presentations 1981 – 2006
    • Literary Presentations and Exhibitions
    • Humanitarian Presentations & Exhibitions
    • Communications on Medical History
  • TELEVISION AND RADIO
    • Medical Presenataions on Radio and Television
    • Historical/Literary Presentations on Radio and Television
  • CAREER OVERVIEW
    • Appointments
    • Learned Societies, Committee Membership, and Editorial Boards
    • Blood Pressue Unit and ADAPT Centre Annual Reports 1996 – 2006
  • SCIENTIFIC BIBLIOGRAPHY
    • Publications 1968 – 1979
    • Publications 1980 – 1989
    • Publications 1990 – 1999
    • Publications 2000 – 2009
    • Publications 2010 – 2016

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