Aliskiren

Stanton A, Jensen C, Nussberger J, O’Brien E. Blood Pressure Lowereing in Essential Hypertension with an Oral Renin Inhibitor, Aliskiren. Hypertension 2003;42:1137-1143

Wood JM, Maibaum J, Rahuel J, Grütter MG, Cohen N-C, Rasetti V, Rüger H, Göschke R, Stutz S, Fuhrer W, Rigollier SP, Yamaguchi, Y, Cumin F, Baum H-P, Schnell C-R, Herold P, Mah R, Jensen C, O’Brien E, Stanton A, Bedigian MP. Structure-based design of aliskiren, a novel orally effective renin inhibitor with antihypertensive efficacy in human patients. Biochemical and Biophysical Research Communications (BBRC) 2003;308:698-705

O’Brien E. Aliskiren: a renin inhibitor offering a new approach for the treatment of hypertension. Expert Opinion on Investigational Drugs 2006;15:1269-1277

O’Brien E, Barton J, Nussberger J, Mulcahy D, Jensen C, Dicker P, Stanton A. Aliskiren provides antihypertensive efficacy and suppression of plasma rennin activity in combination with a thiazide diuretic, an angiotensin converting enzyme inhibito, or an angiotensin receptor blocker. Hypertension 2007;49:276-284