• WELCOME
  • SCIENCE & RESEARCH
  • BLOOD PRESSURE MEASUREMENT
    • History of blood pressure measurement
    • Measurement in low resource settings
    • Guidelines, standards and recommendations
    • Device validation protocols
    • Device validation studies
    • Device validation – State-of-the-market
    • Conventional blood pressure measurement
    • The mercury issue
    • ABPM – General
    • ABPM – Reference values
    • ABPM – Patterns and sub-groups
    • ABPM – Nocturnal blood pressure
    • ABPM – drug assessment
    • ABPM – Elderly
    • ABPM – Pregnancy
    • ABPM – Outcome
    • ABPM – Computer analysis and indices
    • ABPM – Hypotension
    • Self-blood pressure measurement
  • DRUG TREATMENT AND TRIALS
    • General
    • EWPHE Study
    • Syst-Eur Study
    • PROGRESS Study
    • HYVET Study
    • ASCOT Study
    • REASON Study
    • Aliskiren
  • CASE REPORTS
  • COMPUTERISED MANAGEMENT OF CV DISEASE
  • GENERAL AND EDUCATIONAL
  • GENETICS
  • LITERARY AND HISTORICAL
  • BIOGRAPHY
    • Dominic Corrigan
    • Oliver Fitzgerald
    • William Stokes
    • Robert Graves
    • John Cheyne
    • Robert Adams
    • J.D.H. Widdess
    • Walter Sommerville
    • Samuel Beckett
    • A.J. (Con) Leventhal
    • Nevill Johnson
      • Nevill Johnson: Paint the smell of grass
    • Oliver St John Gogarty
    • Denis Johnston
    • Dom Peter Flood
    • Micheal MacLiammoir
    • Petr Skrabanek
  • HISTORY OF MEDICAL INSTITUTIONS
    • A Century of Service: The City of Dublin Skin and Cancer Hospital 1911-2011
    • Royal College of Surgeons in Ireland
    • Royal College of Physicians of Ireland
    • The Charitable Infirmary
    • The Richmond Hospital
    • Beaumont Hospital
  • MISCELLANEOUS ESSAYS AND LETTERS
  • MEDICAL JOURNALISM
  • MEDICAL HISTORICAL EXHIBITIONS
  • PUBLISHING
  • HUMANITARIAN ACTIVITIES
  • COMMUNICATIONS AND PRESENTATIONS
    • Scientific Presentations 1981 – 2006
    • Literary Presentations and Exhibitions
    • Humanitarian Presentations & Exhibitions
    • Communications on Medical History
  • TELEVISION AND RADIO
    • Medical Presenataions on Radio and Television
    • Historical/Literary Presentations on Radio and Television
  • CAREER OVERVIEW
    • Appointments
    • Learned Societies, Committee Membership, and Editorial Boards
    • Blood Pressue Unit and ADAPT Centre Annual Reports 1996 – 2006
  • SCIENTIFIC BIBLIOGRAPHY
    • Publications 1968 – 1979
    • Publications 1980 – 1989
    • Publications 1990 – 1999
    • Publications 2000 – 2009
    • Publications 2010 – 2016
Eoin O'Brien

SCIENCE & RESEARCH

Etienne Jules Marey

INTRODUCTION

I founded the Blood Pressure Unit in 1979 in the Charitable Infirmary, Jervis Street in collaboration with Professor Kevin O’Malley. From the outset the Unit concentrated on research into the pharmacology of blood pressure lowering drugs, particularly in the elderly, and on the development of blood pressure measuring techniques, especially techniques of ambulatory blood pressure measurement.

The Arterial Disease Assessment Prevention and Treatment (ADAPT) Clinic was established in collaboration with Professor David Bouchier-Hayes and Professor Desmond Fitzgerald in Beaumont Hospital 1997. The rationale for this unique clinic was based on the concept that disease of the arterial organ was a fundamental denominator in all-cardiovascular disease. The ADAPT Clinic was established to ensure that all patients with cardiovascular disease, regardless of the speciality to which they presented, would receive the most comprehensive risk factor assessment with appropriate life-style modification and evidence-based drug treatment directed at the arterial organ.

The ADAPT concept was further developed in 1999 with the establishment of the ADAPT Centre, which became the research facility of the Blood Pressure Unit. The ADAPT Centre was committed to the emerging role of translational research in bridging the void between the clinical ‘bedside’ and the laboratory ‘bench’. The ADAPT Centre provided out-patient facilities and a cardiovascular laboratory equipped to perform state-of-the-art cardiovascular assessment that included echocardiography, electrocardiography with stress testing, Holter monitoring, applanation tonometry, pulse wave velocity analysis, 24-hour ambulatory blood pressure monitoring, beat-to-beat non-invasive blood pressure monitoring, 24-hour silent ischaemia monitoring, fundal photography and imaging, and carotid wall (intima-media thickness) imaging. Through its association with the Charitable Infirmary Trust Molecular Medicine Laboratories and the Clinical Research Centre in the RCSI Building at Beaumont Hospital, and with the Department of Clinical Pharmacology, the Centre for Proteomics, SURGEN, and BIOSYS at RCSI, the ADAPT Centre was able to further translational research into the biochemical and genetic markers of risk, thrombosis, and endothelial damage.
Twenty-one Annual Reports, which are listed elsewhere on this website, record the research, scientific presentations and publications, and most importantly the staff who performed the work of the Blood Pressure unit over its 27-year history. These reports give details of over 600 papers published in peer-reviewed journals together with numerous editorials, letters, books, book chapters, general and educational articles and abstracts. The reports also list the scientific and educational presentations made since 1988 in many countries around the world. The following list of papers, many of which are available as pdf files, summarise the scientific output of the Blood Pressure Unit and serve as a history of blood pressure management during this period. For convenience scientific publications pre-dating the foundation of the Blood Pressure Unit are also listed.

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Pages

  • WELCOME
  • SCIENCE & RESEARCH
  • BLOOD PRESSURE MEASUREMENT
    • History of blood pressure measurement
    • Measurement in low resource settings
    • Guidelines, standards and recommendations
    • Device validation protocols
    • Device validation studies
    • Device validation – State-of-the-market
    • Conventional blood pressure measurement
    • The mercury issue
    • ABPM – General
    • ABPM – Reference values
    • ABPM – Patterns and sub-groups
    • ABPM – Nocturnal blood pressure
    • ABPM – drug assessment
    • ABPM – Elderly
    • ABPM – Pregnancy
    • ABPM – Outcome
    • ABPM – Computer analysis and indices
    • ABPM – Hypotension
    • Self-blood pressure measurement
  • DRUG TREATMENT AND TRIALS
    • General
    • EWPHE Study
    • Syst-Eur Study
    • PROGRESS Study
    • HYVET Study
    • ASCOT Study
    • REASON Study
    • Aliskiren
  • CASE REPORTS
  • COMPUTERISED MANAGEMENT OF CV DISEASE
  • GENERAL AND EDUCATIONAL
  • GENETICS
  • LITERARY AND HISTORICAL
  • BIOGRAPHY
    • Dominic Corrigan
    • Oliver Fitzgerald
    • William Stokes
    • Robert Graves
    • John Cheyne
    • Robert Adams
    • J.D.H. Widdess
    • Walter Sommerville
    • Samuel Beckett
    • A.J. (Con) Leventhal
    • Nevill Johnson
      • Nevill Johnson: Paint the smell of grass
    • Oliver St John Gogarty
    • Denis Johnston
    • Dom Peter Flood
    • Micheal MacLiammoir
    • Petr Skrabanek
  • HISTORY OF MEDICAL INSTITUTIONS
    • A Century of Service: The City of Dublin Skin and Cancer Hospital 1911-2011
    • Royal College of Surgeons in Ireland
    • Royal College of Physicians of Ireland
    • The Charitable Infirmary
    • The Richmond Hospital
    • Beaumont Hospital
  • MISCELLANEOUS ESSAYS AND LETTERS
  • MEDICAL JOURNALISM
  • MEDICAL HISTORICAL EXHIBITIONS
  • PUBLISHING
  • HUMANITARIAN ACTIVITIES
  • COMMUNICATIONS AND PRESENTATIONS
    • Scientific Presentations 1981 – 2006
    • Literary Presentations and Exhibitions
    • Humanitarian Presentations & Exhibitions
    • Communications on Medical History
  • TELEVISION AND RADIO
    • Medical Presenataions on Radio and Television
    • Historical/Literary Presentations on Radio and Television
  • CAREER OVERVIEW
    • Appointments
    • Learned Societies, Committee Membership, and Editorial Boards
    • Blood Pressue Unit and ADAPT Centre Annual Reports 1996 – 2006
  • SCIENTIFIC BIBLIOGRAPHY
    • Publications 1968 – 1979
    • Publications 1980 – 1989
    • Publications 1990 – 1999
    • Publications 2000 – 2009
    • Publications 2010 – 2016

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