Syst-Eur Study

Amery A, Birkenhager W, Bulpitt CJ, Clement D, de Leeuw P, Dollery CT, Fagard R, Fletcher A, Forette F, Leonetti G, O’Brien ET, O’Malley K, Rodico JL, Rosenfeld J, Staessen J, Strasser T, Terozoli I, Thijs L, Tuomilehto J, Webster J. Syst-Eur: A multicentre trial on the treatment of isolated systolic hypertension in the elderly: objectives, protocol and organisation. Ageing 1991;3:287-302

Forette F, Amery A, Staessen J, Strasser T, Thijs L, Beevers DG, Bert P, Clement D, Cox J, De Leeuw PW, De Plaen JF, Donnarel G, Escande M, Fagard R, Girerd X, Hickey A, Pandita-Gunawardena ND, Periliat I, Ruilope M, Slovick D, Terozli L, Varis R, Webster RJ. Is prevention of vascular dementia possible? The Syst-Eur Vascular Dementia Project. Aging 1991;3:373-382.

O’Malley K, Cox J, O’Brien E. Choice of Drug Treatment in Elderly Hypertensive Patients. Am J Med 1991;90 (suppl 3A);27S-33S.

Staessen J, Amery A, Birkenhager W, Bulpitt CJ, Cox J, de Leeuw P, DDe Cort P, Fagard R, Fletcher A, Forette F, Fowler G, Girrerd X, Leonetti G, O’Brien ET, O’Malley K, Petrie JC, Rodrico JL, Rosefield J, Slovic W, Terozoli L, Thijs L, Tuomilehto J, Webster J, Yoddfet X. Syst-Eur: a multicentre trial for the treatment of isolated systolic hypertension in the Elderly. First interim report. J Cardiovasc Pharmacol 1992;9:120-125.

Amery A on behalf of the European Working Party on High Blood Pressure in the Elderly. Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly. High Blood Press 1992;1:138-142.

Girerd X, Amery A, Birkenhager W, Bulpitt CJ, Cox J, de Leeuw P, DDe Cort P, Fagard R, Fletcher A, Forette F, Fowler G, Leonetti G, O’Brien ET, O’Malley K, Petrie JC, Rodrico JL, Rosefield J, Slovic W, Staessen J, Terozoli L, Thijs L, Tuomilehto J, Webster J, Yoddfet X.. Syst-Eur un essai multicentrique du traitement de l’hypertension systolique du sujet agé. Arch Mal Coeur 1992;85:1243-1247.

Staessen J, Amery A, Clement D, Cox J, De Cort P, Fagard R, Guo C, Marin R, O’Brien ET, O’Malley K, Mancia G, Parati G, Ravogli A, Thijs L, Webster J. Twenty-four hour blood pressure monitoring in the Syst-Eur trial. Aging Clin Exp Res 1992;4:85-91.

Staessen J, Amery A, Birkenhager W, Bulpitt CJ, Clement D, de Leeuw P, Deruyttere M, De Schaepdryver A, Dollery C, Fagard R, Fletcher A, Forette F, Forte J, Henry J-F, Koistinen G, Leonetti G, Nissinen A, O’Brien E, O’Malley K, Pelemans W, Petrie JC, Strasser TK, Terozoli L, Thijs L, Thijs L, Tuomilehto J, Webster J, Williams BO. Serum cholesterol and survival in elderly hypertensive aptients. In: Hypertension, athersclerosis and lipids. Ed by P.A van Zwieten, G. Mancia and O.E. Brodde. Royal Society of Medicine Services International Congress and Symposium Series. No. 191. Royal Society of Medicine Services Limited. 1992. Pp. 19-26.

Slovick DI, Amery A, Birkenhager W, Bulpitt CJ, Cox J, de Leeuw P, de Cort P, Fagard R, Fletcher A, Forette F, Fowler G, Girerd X, Leonetti G, O’Brien ET, O’Malley K, Petrie J, Rodicio JL, Rosenfeld J, Staessen J, Terzoli L, Thijs L, Tuomiletho J, Webster J, Yodfat Y. SYST-EUR multicentre trial on the treatment of isolated systolic hypertension in the elderly: first interim report. J Human Hypertens 1993;7:201-203.

Staessen J, Bert P, Bulpitt C, De Cort P, Fagard R, Fletcher A, Kivinen P, Lehtomaki E, Leonetti G, O’Brien E, Rodicio J, Rosenfeld J, Thijs L, Tozzi N, Tuomilehto J, Vanhanen H, Vanska O, Webster J, Yodfat Y. Nitrendipine in older patients with isolated systolic hypertension: second progress report on the Syst-Eur trial. J Human Hypertens 1993;7:265-271.

Slovick D, Staessen J, Bert P, Bulpitt C, De Cort P, Fagard R, Fletcher A, Kivinen P, Lehtomaki E, Leonetti G, O’Brien E, Rodicio J, Rosenfeld J, Thijs L, Tozzi N, Tuomilehto J, Vanhanen H, Vanska O, Webster J, Yodfat Y. Nitrendipine in older patients with isolated systolic hypertension: second progress report on the Syst-Eur trial. J Human Hypertens 1993;7:411-412.

Thijs L, Amery A, Antikainen R, Birkenhager W, Bulpitt C, Dollery CT, Fletcher AE, Forette F, Haknaki P, Kvinen E, Lehtomaki E, O’Brien E, Sarti C, Staessen J, Tilvis R, Triarco B, Tuomilehto J, Vannanan H, Vainska B, Webster J, Yodfat Y. Antihypertensive therapy in elderly patients with isolated systolic hypertension: Third progress report on the Syst-Eur Trial. Clin & Exper Hypertension. 1993;15(6):953-966

Fletcher A, Bulpitt C, Amery A, Battersvby C, Cox J, O’Brien E, O’Malley K, Fagard R, Fastido M, Kivinen P, Leonetti G, Slovick D, Staessen J, Terolzi L, Thys L, Tuomilheto J. The assessment of quality of life in the SYST-EUR trial. High Blood Press 1993;2:45-50.

O’Malley K, O’Brien E. Special Clinical Situations. The Elderly. In: The ABCs of Antiypertensive Therapy. Ed. E. Messerli. Raven Press. New York.1994. pp. 187-194

Vanhanen H, Thijs L, Birkenhager W, Tilvis R, Sarti C, Tuomilehto J, Bulpitt C, Fagard R, Staessen J on behalf of the Syst-Eur Investigators. Associations of orthostatic blood pressure fall in older patients with isolated systolic hypertension. J Hypertens 1996;14:943-949.

Vanhanen H, Thijs L, Birkenhager W, Tilvis R, Sarti C, Tuomilehto J, Staessen J on behalf of the Syst-Eur Investigators. Prevalence and persistency of orthostatic blood pressure fall in older patients with isolated systolic hypertension. J Human Hypertens 1996;10:607-612.

Staessen J, Thijs L, Bijltebier G,Clement D, O’Brien ET, Palatini P, Rodicio J, Rosenfeld J, Fagard R on behalf of the Systolic Hypertension in Europe (SYST-EUR) Trial Investigators.. Determining the Trough-to-Peak Ratio in Parallel Group Trials. Hypertension 1997;29:659-667

Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhager WH, Bulpitt CJ, de Leeuw P, Dollery CT, Fletcher AE, Forette F, Leonetti G, Nachev C, O’Brien ET, Rosenfeld J, Rodicio JL, Tuomilehto J, Zanchetti A, for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet.1997;350:757-764

Antikainen R, Tuomilehto J, Thijs L, Vanhanen H, Sarti C, Birkenhager W, Arabidze G, Fagard R, Grigorow M, et al on behalf of the Syst-Eur Investigators. Therapy in old patients with isolated systolic hypertension – fourth progress report on the Syst-Eur trial. J Human Hypertens 1997;11:263-269

Fletcher AE, Bulpitt CJ, Tuomilehto J, Brown J, Bossini A, Kawenck-Jascz K, Kwinen P, O’Brien E, Staessen J, Thijs L, Vanska D, Vanhannen H on behalf of Syst-Eur Trial Investigators. Quality of life in elderly patients with isolated systolic hypertension: baseline data from the Syst-Eur Trial. J Hypertens 1998;16:1117-1124

Seux ML, Thijs L, Forette F, Staessen JA, Birkenhaeger, WH, Bulpitt CJ, Girerd X, Jaaskivi M, Vanhanen H, Kivinen P, Yodfat Y, Vanska O, Antikainen R, Laks T, Webster JR, Hakamaki T, Lehtomaki E, Lilov E, Grigorov M, Janulova K, Halonen K, Kohonen-Jalonen P, Kermowa R, Nachev C, Tuomilehto J. Correlates of cognitive status in older patients with isolated systolic hypertension: the Syst-Eur Vascular Dementia Project . J Hypertens 1998;963-969

Staessen JA, Thijs L, Fagard RH, Birkenhaeger, WH, Arabidze G, Barbeanu S, Gil-Extremera B, Bulpitt CJ, Davidson C, de Leeuw PW, Efstratopoulos AD, Fletcher A, Fogari R, Jaaskivi M, Kawecka-Jaszez K, Nachev C, Petrie JC, Seux M, Tuomilehto J, Webster JR, Yodfat Y for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Calcium Channel Blockade and Cardiovascular Prognosis in the European Trial on Isolated Systolic Hypertension. Hypertension 1998;32:410-416

Forette F, Seux M-L, Staessen J, Thijs L, Birkenhaeger, Babarskiene M-R, Babaneau S, Bossini A, Gil-Extremera B, Girerd X, Laks T, Lilov E, Moisseyev V, Tuomilehto J, Vanhanan H, Webster J, Yodfat Y, Fagard R, on behalf of the Syst-Eur Investigators. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998;352:1347-1351

Bulpitt CJ, Fletcher AE, Thijs L, Staessen J, Antikainen R, Davidson C, Fagard R, Gil-Extremera B, Jääskivi M, O’Brien E, Palatini P, Tuomilehto J, on behalf of SYST-EUR investigators. Symptoms reported by elderly patients with isolated systolic hypertension: baseline data from the SYST-EUR trial. Age and Ageing 1999;28:15-22

Tuomilehto J, Rastenyte D, Birkenhaeger WH, Thijs L, Antikainen R, Bulpitt CJ, Fletcher AE, Forette F, Goldhaber A, Palatini P, Sarti S, Fagard R, (Staessen JA, Arabidze GG, Carrageta M, Celis H, Kocemba J, Leonetti G, Nachev C, O’Brien ET, Ritz E, Rodicio JL, Rosenfeld J, Heyrman J, Stibbe G, Van-den-Haute H, Yodfat Y, Hubner GE) for the Systolic Hypertension in Europe Trial Investigators. Effects of Calcium-Channel Blockade in Older Patients with Diabetes and Systolic Hypertension. N Eng J Med 1999;340:677-84

Staessen JA, Thijs L, Birkenhager WJ, Bulpitt C, Fagard R on behalf of the Syst-Eur Investigators. Update on the Systolic Hypertension in Europe (Syst-Eur) Trial. Hypertension 1999;33:1476-1477

Gasowski J, Staessen JA, Celis H, Fagard RH, Thijs L, Birkenhaeger WH, Bulpitt CJ, Fletcher AE, Arabidze G, de Leeuw PW, Diollery CT, Forette F, Kawecka-Jaszez K, Leonetti G, Nachev C, O’Brien ET, Safar M, Rodico JC, Rosenfeld J, Tuomilehto J, Webster J, Yodfat Y for the Systolic Hypertension in Europe Investigators. Systolic Hypertension in Europe (Syst-Eur) Trial Phase 2: objectives, protocol, and first interim report. J Human Hypertens 1999;13:135-145

Fagard RH, Staessen JA for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Treatment of isolated systolic hypertension in the elderly: further evidence from the SYST-EUR trial. Eur Heart J Supplements 1999;1 (Supplement M): M2-M5

Seux M-L, Forette F, Staessen J, Thijs L, Birkenhaeger, Webster J, Babarskiene M-R, Babaneau S, Bossini A, Gil-Extremera B, Girerd X, Laks T, Lilov E, Moisseyev V, Tuomilehto J, Vanhanan H, Yodfat Y, Fagard R, on behalf of the Syst-Eur Investigators. Treatment of isolated systolic hypertension and dementia prevention in older patients. Eur Heart J Supplements 1999;1 (Supplement M): M6-M12

Forette F, Rigaud AS, Seux M-L, Staessen J, Tjijs L, Birkenhäger WH on behalf of the Systolic Hypertension in Europe investigators. Reduction of dementia by calcium-anatagonist-based antihypertensive treatment. Eur Heart J 2000;2 (Suppl D): D17-D19

Seux M-L, Forette F, Staessen JA, Tjijs L, Birkenhäger WH, Webster J, Babarskiene M-R, Babeanu S, Bossini A, Gill-Extremera B, Girerd X, Laks T, Lilov E, Moisseyev V, Tuomiliehito J, Vanhanen H, Yodfat Y, Fagard R on behalf of the Systolic Hypertension in Europe investigators. Treatment of isolated systolic hypertension and dementia prevention in older patients. Eur Heart J 2000;2 (Suppl M): M6-M12.

Voyaki SM, Staessen JA, Thijs L, Wang JG, Efstratopoulos AD, Birkenhager W, de Leeu PW, Leonetti G, Nachev C, Rodicio JL, Tuomilehto J, Fagard R, for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Follow-up of renal function in treated and untreated older patients with isolated systolic hypertension. J Hypertens 2001;19:511-519

Fagard R, Staessen JA, for the Systolic Hypertension in Europe (Syst-Eur) Trial investigators. Treatment of isolated systolic hypertension in the elderly: further evidence from the Syst-Eur trial. Eur Heart J 2000;2 (Suppl M): M2-M5.

Celis H, Thijs L, Staessen JA, Birkenhager WH, Bulpitt CJ, de Leeuw PW, Leonetti G, Nachev C, Tuomilehto J, Fagard RH for the Syst-Eur investigators. Interaction between nonsteroidal anti-inflammatory drug intake and calcium-channel blocker-based antihypertensive treatment in the Syst-Eur trial. J Human Hypertens 2001;15:613-618

Staessen JA, Fagard RH, Thijs L, for Syst-Eur Onvestigators. The Systolic Hypertension in Europe Trial. In: Clinical Trials in Hypertension, Ed: Black HR, Marcel Dekker Inc., New York, New York, USA, 2001, pp 313-356 (ISBN 0-8247-0270-0).

Staessen JA, Thijs L, Celis H, Gasowski J, Wang JG, Fagard RH. Dihydropyridine calcium-channel blockers for antihypertensive treatment in older patients–evidence from the Systolic Hypertension in Europe Trial. S Afr Med J 2001;91:1060-8

Bulpitt CJ, Beckett NS, Fletcher AE, Thijs L, Staessen JA, Dumitrascu DL, Forette F, Leonetti G, Nachev C, Tuomilehto J, Fagard RH. Withdrawal from treatment in the Syst-Eur Trial. J Hypertens 2002;20:339-46

Thijs L, Staessen JA, Beleva S, Birkenhager WH, Bulpitt CJ, Celis H, Fletcher AE, Kermova R, Leonetti G, Laks T, Mantov S, Nachev C, Sarti C, Tuomilehto J, Fagard RH. How well can blood pressure be controlled? Progress report on the Systolic Hypertension in Europe Follow-Up Study (Syst-Eur 2). Curr Control Trials Cardiovasc Med 2001;2:298-306

Fletcher AE, Bulpitt CJ, Thijs L, Tuomilehto J, Antikainen R, Bossini A, Brown J, Duggan J, Kawecka-Jaszez K, Kivinen P, Sarti C, Terzoli L, Staessen JA, on behalf of the Syst-Eur Trial Investigators. Quality of life on randomised treatment for isolated systolic hypertension: results from the Syst-Eur Trial. J Hypertens 2002;20:2069-2079

Forette F, Seux ML, Staessen JA, Thijs L, Babarskiene MR, Babeanu S, Bossini A, Fagard R, Gil-Extremera B, Laks T, Kobalava Z, Sarti C, Tuomilehto J, Vanhanen H, Webster J, Yodfat Y, Birkenhager WH. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002;162:2046-52

De Leeuw PW, Thijs L, Birkenhager WH, Voyaki SM, Efstratopoulos AD, Fagard RH, Leonetti G, Nachev C, Petrie JC, Rodicio JL, Rosenfeld JJ, Sarti C, Staessen JA. Prognostic significance of renal function in elderly patients with isolated systolic hypertension: results from the Syst-Eur trial. J Am Soc Nephrol. 2002 ;13:2213-22

Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Babarskiene M-R, Babeanu S, Birkenhager W, Bulpitt C, de Leeuw P, Dollery CT, Fletcher A, Forette F, Kocemba J, Laks T, Leonetti G, Nachev C, O’Brien E, Petrie JC, Rodicio JL, Rosenfeld J, Tuomilehto J, Vanhanen H, Webster J, Yodfat Y, Zanchetti A for the Systolic-Hypertension in Europe (Syst-Eur) Trial Investigators. The Systolic Hypertension in Europe Trial. In: Clinical Trial Review of Hypertension Therapy. Ed.Henry Black. US. 2002.

Pringle E, Phillips C, Thijs L, Davidson C, Staessen JA, de Leeuw PW, Jaaskivi M, Nachev C, Parati G, O’Brien ET, Tuomilehto J, Webster J, Bulpitt CJ, Fagard R, on behalf of the Syst-Eur investigators. Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population. J Hypertens 2003;21:2251-2257

Staessen JA, Thijs L, Fagard R, Celis H, Birkenhager WH, Bulpittc CJ, de Leeuw PW, Fletcher AE, Forette F, Leonetti G, McCormack P, Nachevi C, O’Brien E, Rodicio JL, Rosenfeld J, Sarti C, Tuomilehto J, Webster J, Yodfat Y, Zanchetti A for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial. J Hypertens 2004; 22:847-857

Fagard RH, Staessen JA, Thijs L, Celis H, Birkenhager WH,C Bulpitt CJ, de Leeuw PW, Leonetti G, Sarti, Tuomilehto J, Webster J, Yodfat Y, for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Prognostic Significance of Electrocardiographic Voltages and Their Serial Changes in Elderly With Systolic Hypertension. Hypertension. 2004;44:459-464.