Publications 2010 – 2016

2010

Scientific papers
O’Brien E, Atkins N, , Stergiou G, Parati G, Asmar R, Imai Y,Wang J, Mengden T, Shennan A on behalf of the Working Group on Blood Pressure Monitoring of the European Society of Hypertension. European Society of Hypertension International Protocol for the Validation of Blood Pressure Measuring Devices in Adults. 2010 Revision. Blood Press Monit 2010;15:23–38

Stergiou G, Karpettas N, Atkins N, O’Brien E. European Society of Hypertension International Protocol for the validation of blood pressure monitors: A critical review of its application and rationale for revision. Blood Press Monit 2010;15:39–48

Rothwell PM, Howard SC, Dolan E, O’Brien E, Dobson JE, Dahlöf B, Sever PS, Poulter NR. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895–905

Rothwell PM, Howard SC, Dolan E, O’Brien E, Dobson JE, Dahlöf B, Poulter NR, Sever PS on behalf of the ASCOT-BPLA and MRC Trial Investigators Effects of β blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurology 2010;9:469-480

Hansen TW, Thijs L, Li Y, Boggia J, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Jeppesen J, Torp Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Wang J, Ibsen H, O’Brien E, Staessen JA on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Prognostic Value of Reading-to-Reading Blood Pressure Variability over 24 Hours in 8938 Subjects from 11 Populations. Hypertension. 2010;55:1049-1057.

Vangjeli C, Clarke N, Quinn U, Dicker P, Tighe O, Ho C, O’Brien E, Stanton AV. Confirmation that the renin gene distal enhancer polymorphism REN-5312C/T is associated with increased blood pressure. Circ Cardiovasc Genet 2010; 3:53-9

Parati g, Stergiou GS, Asmar R, Bilo G, de Leeuw P, Imai Y, Kario K, Lurbe E, Manolis A, Mengden T, O’Brien E, Ohkubo T, Padfield P, Palatini P, Pickering TG, Redon J, Revera M, Ruilope LM, Shennan A, Staessen JA, Tisler A, Waeber B, Zanchetti A, Mancia G on behalf of ESH Working Group on Blood Pressure Monitoring. European Society of Hypertension Practice Guidelines for home blood pressure monitoring. J Hum Hypertens. 2010 Jun 3. [Epub ahead of print]

Thijs L, Richart T, de Leeuw PW, Kuznetsova T, Grodzicki T, Kawecka-Jaszcz K, OʼBrien E, Redón J, Birkenhäger WH, Fagard R, Staessen JA. Morbidity and mortality on combination versus monotherapy: a posthoc analysis of the Systolic Hypertension in Europe trial. J Hypertens. 2010;28:865-74.

Sharp AS, Tapp RJ, Thom SA, Francis DP, Hughes AD, Stanton AV, Zambanini A, O’Brien E, Chaturvedi N, Lyons S, Byrd S, Poulter NR, Sever PS, Mayet J; on behalf of the ASCOT Investigators. Tissue Doppler E/E’ ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy. Eur Heart J. 2010;31:747-752.

Tapp RJ, Sharp AS, Stanton AV, O’Brien E, Chaturvedi N, Poulter NR, Sever PS, Thom SA McG, Hughes AD, Mayet J on behalf of the ASCOT Investigators. Differential Effects of Anti-hypertension Treatment on Left Ventricular Diastolic Function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial ) sub-study. JACC 2010;55:1875-81

McGowan N, Atkins N, O’Brien E, Padfield P. Computerised reporting improves the clinical use of ambulatory blood pressure measurement. Blood Press Monit 2010.15:115–123

O’Brien E. Ambulatory blood pressure monitoring: 24-hour blood pressure control as a therapeutic goal for improving cardiovascular prognosis. Medicographia 2010;32:241-249

Fan HQ, Li Y, Thijs L, Hansen TW, Boggia J, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Ibsen H, OʼBrien E, Wang J, Staessen JA; on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations. J Hypertens 2010, 28:2036–2045

Kikuya M, Staessen JA, Ohkubo T, Thijs L, Asayama K, Satoh M, Hashimoto T, Hirose T, Metoki H, Obara T, Inoue R, Li Y, Dolan E, Hoshi H, Totsune K, Satoh H, Wang J, O’Brien E, Imai Y. How many measurements are needed to provide reliable information in terms of the ambulatory arterial stiffness index? the Ohasama study. Hypertens Res 2010; 1–5 advance online publication, 2 December 2010; doi:10.1038/hr.2010.240

Parati G, Ochan Kilama M, Faini A, Facelli E, Ochen K, Opira C, Mendis S, Wang J, Atkins N, O’Brien E. A new solar powered blood pressure measuring device for low resource settings. Hypertension 2010;56;1047-1053

Waeber B, Mourad JJ, O’Brien E. Nighttime blood pressure: a target for therapy? Curr Hypertens Rep 2010;12:474-9.

Participating investigator Li Y, Thijs L, Hansen TW, Kikuya M, Boggia J, Richart T, Metoki H, Ohkubo T, Torp Pedersen C, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Sandoya E, Kawecka-Jaszcz K, Ibsen H, Imai Y, Wang J, Staessen JA on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Prognostic Value of the Morning Blood Pressure Surge in 5645 Subjects From 8 Populations. Hypertension 2010; 55:1040 – 1048.

Editorials
O’Brien E, White W. Thomas G. Pickering: friend, colleague and scientist. Blood Press Monit 2010, 15:67–69

Dolan E, O’Brien E. Blood Pressure Variability: Clarity for Clinical Practice. Hypertension 2010;56:179-181

O’Brien E, Stergiou G. Who will bell the cat? A call for a new approach for validating blood pressure measuring devices. J Hypertens 2010,28:2378–2381

Letters
O’Brien E. An endothelin antagonist for resistant hypertension. Lancet.2010;375:635-637

Staessen JA, O’Brien E. Clinical thresholds for ambulatory blood pressure measurement reinvented? Rapid response to Head GA, Milhailidou AS, Duggan KA, Beilin LJ, Berry N, Brown MA et al. Definition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study. BMJ 2010. on-line 30 April 2010. 340: c1104.

Dolan E, O’Brien E. Response to Increased Intervisit Blood Pressure Variability and β Blockade: Measurement imprecision Related to Bradycardia? Hypertension 2010 published online Sep 13, 2010

General and Educational
O’Brien E. Clinical developments in hypertension management. Irish Medical Times. 26.03.2010. p.vii

O’Brien E. Too many guidelines. Cardiology Supplement. Irish Medical News 28.01.2010. p.40

Stergiou G, Karpettas N, Atkins N, O’Brien E.ESH-IP for the validation of blood-pressure monitors; a success story and its future. International Hospital Equipment. 2010;7:6-7.

O’Brien E. Blood pressure variability: clarity for clinical practice. Irish Medical Times 30.04.2010. p.54

O’Brien E. Second opinion. The vital facts that influence mortality rates. Irish Times. 16.11.2010.

O’Brien E. Technology can help us to reduce the incidence of high blood pressure. Health Matters 2010.p.79-81.

2011

Scientific papers
Boggia J, Thijs L, Hansen TW, Li Y, Kikuya M, Bjorklund-Bodegård K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, T Kuznetsova, Olszanecka A, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Maestre G, Sandoya E, Kawecka-Jaszcz E, Imai Y, Wang J, Ibsen H, O’Brien E, Staessen JA, on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Ambulatory Blood Pressure Monitoring in 9357 Subjects From 11 Populations Highlights Missed Opportunities for Cardiovascular Prevention in Women. Hypertension. 2011;57:397-405.

Jin Y, Thijs L, Richart T, Li Y, Dolan ed, Wang J-G, Protogerou A, O’Brien E, Staessen JA, Safar M on behalf of the REASON Investigators. Responses of the ambulatory arterial stiffness index and other measures of arterial function to antihypertensive drugs. Hypertens Research 2011;34:489-495.

Stergiou GS, Karpettas N, Atkins N, O’Brien E. Impact of applying the more stringent validation criteria of the revised European Society of Hypertension International Protocol 2010 on earlier validation studies. Blood Press Monit 2011;16:67–73

O’Brien E. 24-hour ambulatory blood pressure measurement in clinical practice and research: a critical review of a technique in need of implementation . J Int Med 2011; 269:478–495.

Kikuya M, Staessen JA, Ohkubo T, Thijs L, Metoki H, Asayama K, Obara T, Inoue R, Li Y, Dolan E, Hoshi H, Hashimoto J, Totsune K, Satoh H, Wang J-G, O’Brien E, Imai Y. How many measurements are needed to provide reliable information in terms of the ambulatory arterial stiffness index? The Ohasama study. Hypertens Res 2011;34:314-8.

O’Brien E. The value of 24-hour blood pressure monitoring to assess the efficacy of antihypertensive drug treatment. Hot Topics in Hypertension 2011;4:7-23

O’Brien E. What to do when faced with an unmeasurable ambulatory blood pressure? J Hypertens 2011, 29:451–453

O’Brien E. Why ABPM Should Be Mandatory in All Trials of Blood Pressure–Lowering Drugs. Drug Information J 2011;45:233–239.

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RM, Tzoulaki J, O’Brien ET, Poulter NR, Sever P et al. Blood Pressure Loci Identified with a Gene-Centric Array. Am J Hum Gen 2011;89:688-700.

O’Brien E. Why ABPM Should Be Mandatory in All Trials of Blood Pressure–Lowering Drugs. J Clin Studies 2011;3:52-55

Collier DJ, et al on behalf of the ASCOT Investigators. Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial. Blood Pressure Lowering Arm. (ASCOT-BPLA). J Hypertens 2011;29:583–591.

Gupta AK, et al on behalf of the ASCOT investigators. Baseline predictors of resistant hypertension in the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT): a risk score to identify those at high-risk. J Hypertens 2011;29:2004–2013.

Collier DJ, et alJ on behalf of the ASCOT Investigators. Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm. J Hypertens 2011;29:592–599.

Editorials
O’Brien E, Parati G. Reverting to simplicity: palpating systolic blood pressure. J Hypertens 2011, 29:27–28

Letters
O’Brien E. ABPM part of FDA reviews. Drug Information J 2011;45:567-568.

General and Educational
O’Brien E. ABPM saves not only money but also lives. Ir Med Times 2011.10.14;52.

O’Brien E. NICE guideline to revolutionise our views on hypertension. Ir Med Times 2011.08.04;44.

O’Brien E. The pressure is on to measure up 24/7. Irish Times 2011;03.29.

O’Brien E. ROADMAP – fact and fallacy in one paper. Ir Med Times 2011.06.05;44.

O’Brien E. NICE guideline will revolutionise the way we manage hypertension. IPU Review 2011.19-20.

O’Brien E. NICE guideline will revolutionise the way we manage hypertension. Hospital Pharmacy News 2011. IPU Review 2011;July:19-20

O’Brien E. A breakthrough for measuring BP in the developing world. Ir Med Times 2011.01.14;27.

O’Brien E. Blood Pressure Variability: a new target. Journal by Fax 2011

O’Brien E. Average Blood Pressure Vs. Blood Pressure Variability. American Society of Hypertension. ASH Circulation 2011.6

O’Brien E. ABPM in Blood Pressure Trials. Advantages of ABPM in Blood Pressure Lowering Trials. 2011. Applied Clinical Trials. http://appliedclinicaltrialsonline.findpharma.com/appliedclinicaltrials/article/articleDetail.jsp?id=746505.

2012

Scientific papers
Franklin SS, Thijs L, Hansen TW, Li Y, Boggia J, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Wang J, Ibsen H, O’Brien E, Staessen JA. Significance of White-Coat Hypertension in Older Persons With Isolated Systolic Hypertension: A Meta-Analysis Using the International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Population. Hypertension.2012;59:564-571

O’Brien E. Stabilizing blood pressure variability: a new therapeutic target in hypertension. Medicographia 2012;34:25-31

Stergiou GS, Parati G, Asmar R, O’Brien E on behalf of the European Society of Hypertension Working Group on Blood Pressure Monitoring. Requirements for professional office blood pressure monitors. J Hypertens 2011;30:537-542

O’Brien E. First Thomas Pickering Memorial Lecture: Ambulatory Blood Pressure Measurement is Essential for the Management of Hypertension. J Clin Hypertens 2012;12:836-847. DOI: 10.1111/j.1751-7176.2012.00698.x

Kollias A, Stergiou GS, Dolan E, O’Brien E. Ambulatory arterial stiffness index: A systematic review and meta-analysis. Atherosclerosis 2012;224:291-301.

O’Brien E. Blood pressure measurement. Why, how, when and where. S Afr Fam Pract 2012;54:Suppl 2:S9-S11

Sever PS, Chang CL, Gupta AK, Whitehouse A, Poulter NA and ASCOT Investigators. The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the U.K. Eur Heart J 2011;32:2525-32.

Sever PS, Poulter NA ,Chang CL, Hingorani A, Thom SA, Hughes AD, Welsh P, Sattar N on behalf of the ASCOT Investigators. Evaluation of C-reactive protein prior to and on-treatment as a predictor of benefit from atorvastatin: observations from the Anglo-Scandinavian Cardiac Outcomes Trial. Eur Heart J 2012;33:486–494

Letters
Velinga A, Murphy A, O’Brien E. Thirty-minute compared to standardized office blood pressure measurement in general practice. (RAMBLER Study). Brit J Gen Pract 2012;126

Stergiou GS, Karpettas N, Atkin N, O’Brien E. The European Society of Hypertension International Protocol for the validation of blood pressure measuring devices in adults.. Response to letter by Gallick D., Friedman B.A., Alpert B.S., Seller J.D., Quinn D.E., and Osborn D. Blood Press Monit 2012; 17:45–47

General and Educational
O’Brien E. ABPM vital in hypertension management. Pickering Memorial Lecture. Irish Medical Times 31.08.2012;33.

O’Brien E. Insight and inspiration. Tuesdays with Morrie. Irish Medical Times 02.10.2012.

O’Brien E. Managing hypertension in diabetic patients. Irish Medical Times 10.02.2012;30
O’Brien E. Renal denervation technique shows promise. Irish Medical Times 30.03.2012;32

O’Brien E. One simple question: will the King of Bahrain implement the recommendations of the BICI? Irish Medical Times 30.03.2012;19

O’Brien E. The Mediterranean diet and health. Irish Medical Times Calendar 2013

2013

Scientific papers
O’Brien E, Turner R. Assessing Blood Pressure Responses to Noncardiovascular Drugs: The Beneficial Role of Ambulatory Blood Pressure Monitoring. J Clin Hypertens (Greenwich) 2013;15:55-62

O’Brien E, Parati G, Stergiou G, et al, on behalf of the European Society of Hypertension Working Group on Blood Pressure Monitoring. ESH Position Paper on Ambulatory Blood Pressure Monitoring. J Hypertens 2013.31.1731-1767

O’Brien E, Parati G, Stergiou G. Ambulatory blood pressure measurement: what is the International Consensus? Hypertension 2013; 62:988-994.
Turner R, O’Brien E. Diagnosis and Treatment of Resistant Hypertension: The Critical Role of Ambulatory Blood Pressure Monitoring, J Clin Hypertens (Greenwich) 2013;15:868-73.

Franklin SS, Thijs L, Hansen TW, O’Brien E, Staessen JA. White-Coat Hypertension: New Insights From Recent Studies. Hypertension 2013;62:982-987.

Franklin SF, Thijs L, Li Y, Hansen TW, Boggia J, Liu Y, Asayama K, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Filipovský J, Imai Y, Wang J, Ibsen H, O’Brien E, Staessen JA and on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Masked Hypertension in Diabetes Mellitus : Treatment Implications for Clinical Practice. Hypertension. 2013;61:964-971

Boggia J, Thijs L, Li Y, Hansen TW, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia e, Nikitin Y, Lind L, Schwedt E, Sandoya E, Kawecka-Jaszcz K, Filipovský J, Imai Y, Wang J, Ibsen H, O’Brien E, Staessen JA and on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Risk Stratification by 24-Hour Ambulatory Blood Pressure and Estimated Glomerular Filtration Rate in 5322 Subjects From 11 Populations. Hypertension. 2013;61:18-26

Editorials
O’Brien E. Exhibition: Illness through the eye of the artist. Lancet 2013;381:618

Mendis S, O’Brien E, Seedat YK, Yusuf S. Hypertension and Diabetes: Entry Points for Prevention and Control of the Global Cardiovascular Epidemic. Int J Hypertens 2013;2013.1-3.

Letters
O’Brien E. Loss of reason. Lancet 2013;381;996

General and Educational
O’Brien E.A Charter for Medical Neutrality. Irish Medical Times 2013.04.19

Dolan E, O’Brien E. Where are our policymakers? Irish Medical Times 2013.01.25

O’Brien E. ABPM should be available to all with hypertension. Irish Medical Times 2013.08.30

O’Brien E. Cost-saving, not cost-cutting is the way to go. Irish Medical Times 2013.11.15

2014

Scientific papers
Turner R, O’Brien E. Inferences Beyond a Study Design’s Grasp: A Cautionary Case Study From the Recent Renal Sympathetic Denervation Literature. Therapeutic Innovation & Regulatory Science. 2014; 1-7. DOI DOI: 10.1177/2168479014539152

James K, Dolan E, O’Brien E. Making ambulatory blood pressure monitoring accessible in pharmacies. Blood Press Monit. 2014, 19:134–139

Persu A, O’Brien E, Verdecchia P. Use of ambulatory blood pressure measurement in the definition of resistant hypertension: a review of the evidence. Hypertension Research. 2014; 17 April 2014; doi:10.1038/hr.2014.83

Barron AJ, Hughes AD, Sharp A, Baksi AJ, Surendran P, Jabbour RJ, Stanton A,Poulter N, Fitzgerald D, Sever P, O’Brien E, Thom S, Mayet J; on behalf of the ASCOT Investigators. Long-Term Antihypertensive Treatment Fails to Improve E/e’ Despite Regression of Left Ventricular Mass: An Anglo-Scandinavian Cardiac Outcomes Trial Substudy. Hypertension. 2014;63:252-258

Modesti PA, Agostoni P, Agyemang C, Basu S, Benetos A, Cappuccio FP, Ceriello A, Del Prato S, Kalyesubula R, O’Brien E, Kilama MO, Perlini S, Picano E, Reboldi G, Remuzzi G, Stuckler D, Twagirumukiza M, Van Bortel LM, Watfa G, Zhao D, Parati G; ESH Working Group on Hypertension and Cardiovascular Risk in Low Resource Settings. Cardiovascular risk assessment in low-resource settings: a consensus document of the European Society of Hypertension Working Group on Hypertension and Cardiovascular Risk in Low Resource Settings. J Hypertens. 2014;32:951-60

Parati G, Stergiou G, O’Brien E, Asmar R, Beilin L, Bilo G, Clement D, de la Sierra A, de Leeuw P, Dolan E, Fagard R, Graves J, Head GA, Imai Y, Kario K, Lurbe E, Mallion JM, Mancia G, Mengden T, Myers M, Ogedegbe G, Ohkubo T, Omboni S, Palatini P, Redon J, Ruilope LM, Shennan A, Staessen JA, vanMontfrans G, Verdecchia P, Waeber B, Wang J, Zanchetti A, Zhang Y; European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability. European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring. J Hypertens. 2014 Jul;32(7):1359-66. doi: 10.1097/HJH.0000000000000221. PubMed PMID: 24886823.

Sever PS, Poulter NR, Chang CL, Thom SA, Hughes AD, Welsh P, Sattar N; ASCOT Investigators. Evaluation of C-reactive protein before and on-treatment as a predictor of benefit of atorvastatin: a cohort analysis from the Anglo-Scandinavian Cardiac Outcomes Trial lipid-lowering arm. J Am Coll Cardiol. 2013;62:717-29.

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JM, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Melander O, Nelson CP, Nolte IM, Pankratz N, Price TS, Shaffer J, Shah S, Tomaszewski M, van der Most PJ, Van Iperen EP, Vonk JM, Witkowska K, Wong CO, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Brown M, Burt A, Cooper-DeHoff RM, Connell JM, Cruickshanks KJ, Curtis SP, Davey-Smith G, Delles C, Gansevoort RT, Guo X, Haiqing S, Hastie CE, Hofker MH, Hovingh GK, Kim DS, Kirkland SA, Klein BE, Klein R, Li YR, Maiwald S, Newton-Cheh C, O’Brien ET, Onland-Moret NC, Palmas W, Parsa A, Penninx BW, Pettinger M, Vasan RS, Ranchalis JE, M Ridker P, Rose LM, Sever P, Shimbo D, Steele L, Stolk RP, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Wyatt S, Young JH, Zwinderman AH, Bezzina CR, Boerwinkle E, Casas JP, Caulfield MJ, Chakravarti A, Chasman DI, Davidson KW, Doevendans PA, Dominiczak AF, FitzGerald GA, Gums JG, Fornage M, Hakonarson H, Halder I, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, Kumari M, März W, Murray SS, O’Connell JR, Oldehinkel AJ, Pankow JS, Rader DJ, Redline S, Reilly MP, Schadt EE, Kottke-Marchant K, Snieder H, Snyder M, Stanton AV, Tobin MD, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Watkins H, Johnson AD, Reiner AP, Zhu X, de Bakker PI, Levy D, Asselbergs FW, Munroe PB, Keating BJ. Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet. 2014;94:349-60.

Gu Y-M, Thijs L, Li Y, Asayama K , Boggia J, Hansen TW, Liu Y, Ohkubo T, Björklund-Bodegård K, Jeppesen J, Dolan E, Torp-Pedersen C, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Mena LJ, Wang J, O’Brien E, Verhamme P, Filipovsky J, Maestre GE, Staessen JA and on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Outcome-Driven Thresholds for Ambulatory Pulse Pressure in 9938 Participants Recruited From 11 Populations. Hypertension. 2014;63:229-237

Li Y, Thijs L, Boggia J, Asayama K, Hansen TW, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Filipovsky J, Imai Y, Ibsen H, O’Brien E, Wang J, Staessen JA; International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Blood pressure load does not add to ambulatory blood pressure level for cardiovascular risk stratification. Hypertension. 2014;63:925-33.

Hansen TW, Thijs L, Li Y, Boggia J, Liu Y, Asayama K, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Filipovský J, Imai Y, Wang J, O’Brien E, Staessen JA. Ambulatory blood pressure monitoring for risk stratification in obese and non-obese subjects from 10 populations. J Hum Hypertens. 2014 Jan 16. doi: 10.1038/jhh.2013.145. [Epub ahead of print] PubMed PMID: 24430701.

Persu A, Renkin J, Asayama K, O’Brien E, Staessen JA. Renal denervation in treatment-resistant hypertension: the need for restraint and more and better evidence. Expert Rev Cardiovasc Ther. 2013;11:739-49.

Brguljan-Hitij J, Thijs L, Li Y, Hansen TW, Boggia J, Liu YP, Asayama K, Wei FF, Bjorklund-Bodegard K, Gu YM, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Katarzyna SS, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Filipovsky J, Imai Y, Wang J, O’Brien E, Staessen JA; on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcome Investigators. Risk Stratification by Ambulatory Blood Pressure Monitoring Across JNC Classes of Conventional Blood Pressure. Am J Hypertens. 2014 Feb 26. [Epub ahead of print] PubMed PMID:24572704.

Campbell NR, Berbari AE, Cloutier L, Gelfer M, Kenerson JG, Khalsa TK, Lackland DT, Lemogoum D, Mangat BK, Mohan S, Myers MG, Niebylski ML, O’Brien E, Stergiou GS, Veiga EV, Zhang XH. Policy Statement of the World Hypertension League on Noninvasive Blood Pressure Measurement Devices and Blood Pressure Measurement in the Clinical or Community Setting. J Clin Hypertens (Greenwich). 2014 May 8. doi: 10.1111/jch.12336. [Epub ahead of print] PubMed PMID: 24811572.

Mena LJ, Maestre GE, Hansen TW, Thijs L, Liu Y, Boggia J, Li Y, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L,Sandoya E, Kawecka-Jaszcz K, Filipovsky J, Lmai Y, Wang J, O’Brien E, StaessenJA; International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO) Investigators. How many measurements are needed to estimate blood pressure variability without loss of prognostic information? Am J Hypertens. 2014 Jan;27(1):46-55. doi: 10.1093/ajh/hpt142. Epub 2013 Aug 16.PubMed PMID: 23955605; PubMed Central PMCID: PMC3848629.

Asayama K, Thijs L, Li Y, Gu YM, Hara A, Liu YP, Zhang Z, Wei FF, Lujambio I, Mena LJ, Boggia J, Hansen TW, Björklund-Bodegård K, Nomura K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Stolarz-Skrzypek K, Malyutina S, Casiglia E, Nikitin Y, Lind L, Luzardo L, Kawecka-Jaszcz K, Sandoya E, Filipovský J, Maestre GE, Wang J, Imai Y, Franklin SS, O’Brien E, Staessen JA; International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO0 Investigators. Setting thresholds to varying blood pressure monitoring intervals differentially affects risk estimates associated with white-coat and masked hypertension in the population. Hypertension. 2014 Nov;64(5):935-42. doi: 10.1161/HYPERTENSIONAHA.114.03614. Epub 2014 Aug 18. PubMed PMID: 25135185.

Conen D, Aeschbacher S, Thijs L, Li Y, Boggia J, Asayama K, Hansen TW, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Gu YM, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Schoen T, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Mena L, Maestre GE, Filipovský J, Imai Y, O’Brien E, Wang JG, Risch L, Staessen JA. Age-specific differences between conventional and ambulatory daytime blood pressure values. Hypertension. 2014 Nov;64(5):1073-9. doi: 10.1161/HYPERTENSIONAHA.114.03957. Epub 2014 Sep 2. PubMed PMID: 25185130.

Franklin SS, O’Brien E, Thijs L, Asayama K, Staessen JA. Masked Hypertension: A Phenomenon of Measurement. Hypertension. 2014 Oct 6. pii: HYPERTENSIONAHA.114.04522. [Epub ahead of print] PubMed PMID: 25287401.

O’Brien E. End of the Joint National Committee heritage? Hypertension. 2014;63:904-6. doi: 10.1161/HYPERTENSIONAHA.113.03097. Epub 2014 Feb 3. PubMed PMID: 24491389.

O’Brien E. If I Had Resistant Hypertension. Hypertension. 2014 Aug 11. pii:HYPERTENSIONAHA.114.04158. [Epub ahead of print] PubMed PMID: 25113965.

Letters
O’Brien E, Parati G, Stergiou G. Response to: nocturnal blood pressure dipping: systolic, diastolic or both? J Hypertens. 2014;32:700-1.

O’Brien E. Renal denervation for resistant hypertension— the Symplicity HTN-1 study. Lancet 2014;383:1884

O’Brien.ABPM-in-pharmacies.BPMonit-2014-copy.pdf”>O’Brien E. In response: Ambulatory blood pressure measurement in pharmacies. Blood Press Monit. 2014;19:372-4. doi: 10.1097/MBP.0000000000000074. PubMed PMID: 25115622.

General and educational
O’Brien E. Renal denervation: the need for more analysis. Irish Medical Times 2014.01.24.p.24

O’Brien E. US hypertension guidelines in disarray. Irish Medical Times 2014.02.14.p.22

O’Brien E. Renal denervation: latest trial shows technique is ineffective. Irish Medical Times 2014.04.14.p.23

O’Brien E. Getting the measure of high blood pressure. Irish Times. 27.05.2014

www.BP2TV.ie The why, how, when and where of BP measurement. Irish Medical Times 2014.08.29.p.24

O’Brien E. Recent Developments in Hypertension Management. The Consultant 2014.65-67.

O’Brien E. Single-pill combinations to improve blood pressure control. Irish Medical Times 2014.08.9.p.24

O’Brien E. Skin deep. Pan European Networks: Science & Technology 2014;13:1-2

O’Brien E. The great salt debate: too much or too little. Irish Medical Times 2014.09.14.p.30

O’Brien E. See no evil, hear no evil. Irish Medical Times 2014.05.09.p.28

O’Brien E. A tweet to jail: Bahrain in 2014. Irish Medical Times 2014.10.17.p.24.17-18.

O’Brien E. Nevill Johnson 1911-1999. Artist, Writer, Photographer. Lilliput Press. Dublin. 2014.

O’Brien E. Nevill Johnson: The Dublin Legacy. Anniversary Press. Dublin. 2014.

2015
Scientific papers

O’Brien E, Dolan E, Atkins N. Failure to Provide ABPM to All Hypertensive Patients Amounts to Medical Ineptitude. J Clin Hypertens (Greenwich). 2015:17:462-5.

Turner R, O’Brien E. Inferences Beyond a Study Design’s Grasp; A Cautionary Case Study From the Recent Renal Sympathetic Denervation Literature. Therapeutic Innovation & Regulatory Scinece 2015;49:86-92.

Lee J, Chee Y, Kim I, Karpettas N, Kollias A, Atkins N, Stergiou GS, O’Brien E. High-fidelity digital recording and playback sphygmomanometry system: device description and proof of concept. Blood Press Monit. 2015;20:266-272.

O’Brien E. Prognostic Value of Ambulatory Blood Pressure Monitoring in Obese Patients. J Clin Hypertens (Greenwich). 2015; 2015 Oct 5. doi: 10.1111/jch.12704. [Epub ahead of print] PubMed PMID: 26434378.

O’Flynn AM, Dolan E, Curtin RJ, O’Brien E, Perry IJ, Kearney PM. Night-time blood pressure and target organ damage: a comparative analysis of absolute blood pressure and dipping status. J Hypertens. 2015:;3:2257-64.

Dolan E, O’Brien E. Is It Daily, Monthly, or Yearly Blood Pressure Variability that Enhances Cardiovascular Risk? Curr Cardiol Rep. 2015;17:93-98.

Kollias A, Rarra V, Karpettas N, Roussias L, O’Brien E, Stergiou GS. Treatment-induced changes in ambulatory arterial stiffness index: one-year prospective study and meta-analysis of evidence. Hypertens Res. 2015;38:627-31.

Draman MS, Dolan E, van der Poel L, Tun TK, McDermott JH, Sreenan S, O’Brien E. The importance of night-time systolic blood pressure in diabetic patients: Dublin Outcome Study. J Hypertens. 2015;33:1373-7.

General and educational

O’Brien E. Migrant crisis. Irish Times 2015;Sept 1st.

O’Brien E. Renal denervation: update on a scientific debacle. Irish Medical Times 2015;Sept 09.27-28.

O’Brien E. Freedoms at the heart of medical education. Irish Medical Times 2015;Feb 13.38.

O’Brien E. Prose with Skirts. The Crossdresser’s Secret by Brian O’Doherty. Dublin Review of Books.16.10.2015

O’Brien E. Why ABPM must be made available to all. Irish Medical Times 2015;Nov 27.20.

2016

Scientific papers

O’Brien E. Why Is It That We Continue to Deny Patients Ambulatory Blood Pressure Monitoring? Hypertension. 2016;67:484-7.

Odili AN, Thijs L, Hara A, Wei FF, Ogedengbe JO, Nwegbu MM, Aparicio LS, Asayama K, Niiranen TJ, Boggia J, Luzardo L, Jacobs L, Stergiou GS, Johansson JK, Ohkubo T, Jula AM, Imai Y, O’Brien E, Staessen JA. Prevalence and Determinants of Masked Hypertension Among Black Nigerians Compared With a Reference Population. Hypertension. 2016;67:1249-55.

O’Brien E. Prognostic Value of Ambulatory Blood Pressure Monitoring in Obese Patients. J Clin Hypertens (Greenwich). 2016;18:119-20.

Salles GF, Reboldi G, Fagard RH, Cardoso CR, Pierdomenico SD, Verdecchia P, Eguchi K, Kario K, Hoshide S, Polonia J, de la Sierra A, Hermida RC, Dolan E, O’Brien E, Roush GC; ABC-H Investigators. Prognostic Effect of the Nocturnal Blood Pressure Fall in Hypertensive Patients: The Ambulatory Blood Pressure Collaboration in Patients With Hypertension (ABC-H) Meta-Analysis. Hypertension. 2016;67:693-700.

O’Brien E. Why Is It So Difficult to Influence the Clinical Management of Hypertension? J Clin Hypertens (Greenwich). 2016;18:606-607.

O’Brien E, Dolan E. Ambulatory Blood Pressure Monitoring for the effective management of Antihypertensive Drug Treatment. Clin Ther. 2016;38:2142-2151.

Stergiou GS, Parati G, Vlachopoulos C, Achimastos A, Andreadis E, Asmar R, Avolio A, Benetos A, Bilo G, Boubouchairopoulou N, Boutouyrie P, Castiglioni P, de la Sierra A, Dolan E, Head G, Imai Y, Kario K, Kollias A, Kotsis V, Manios E, McManus R, Mengden T, Mihailidou A, Myers M, Niiranen T, Ochoa JE, Ohkubo T, Omboni S, Padfield P, Palatini P, Papaioannou T, Protogerou A, Redon J, Verdecchia P, Wang J, Zanchetti A, Mancia G, O’Brien E. Methodology and technology for peripheral and central blood pressure and blood pressure variability measurement: current status and future directions – Position statement of the European Society of Hypertension Working Group on blood pressure monitoring and cardiovascular variability. J Hypertens. 2016;34:1665-77.

Franklin SF, Thijs l, Asayama K, Li Y, Hansen TW, Boggia j,Jacobs l,Zhang Z, Kikuya M, Björklund-Bodegård K, Ohkubo T, Yang, W, Jeppesen j, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin y, Lind L, Sandoya E, Kawecka-Jaszcz K, Filipovský J, Imai Y, Wang JG, O’Brien E. Staessen JS. on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. The Cardiovascular Risk of “White-Coat” Hypertension. J Am Coll Cardiol. 2016;68:2033-2043.

Innovative approaches to prevention: Tackling the global burden of cardiovascular disease. Report of the WISH Cardiovascular Disease Forum 2016. Qatar 2016. Pp 1-48.

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ, Cummings SR, Denny JC, Dubé MP, Durrington PN, Eiriksdottir G, Ford I, Guo X, Harris TB, Heckbert SR, Hofman A, Hovingh GK, Kastelein JJ, Launer LJ, Liu CT, Liu Y, Lumley T, McKeigue PM, Munroe PB, Neil A, Nickerson DA, Nyberg F, O’Brien E, O’Donnell CJ, Post W, Poulter N, Vasan RS, Rice K, Rich SS, Rivadeneira F, Sattar N, Sever P, Shaw-Hawkins S, Shields DC, Slagboom PE, Smith NL, Smith JD, Sotoodehnia N, Stanton A, Stott DJ, Stricker BH, Stürmer T, Uitterlinden AG, Wei WQ, Westendorp RG, Whitsel EA, Wiggins KL, Wilke RA, Ballantyne CM, Colhoun HM, Cupples LA, Franco OH, Gudnason V, Hitman G, Palmer CN, Psaty BM, Ridker PM, Stafford JM, Stein CM, Tardif JC, Caulfield MJ, Jukema JW, Rotter JI, Krauss RM. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. J Med Genet. 2016;53:835-845.

Dolan E, O’Brien E. Comparing the therapeutic merits of angiotensin receptor blockers. J Hypertens. 2016;34:1052-4.

O’Brien E. Salt–too much or too little? Lancet. 2016;388:439-40.

Franklin SS, O’Brien E, Staessen JA. Masked hypertension: understanding its complexity. Eur Heart J. 2016 Nov 10. pii: ehw502. [Epub ahead of print] PubMed PMID: 27836914.

Dolan E, O’Brien E. How should ambulatory blood pressure measurement be used in general practice? J Clin Hypertens (Greenwich). 2016;In press

O’Brien E. How registries can guide our future. Hypertension. 2016. In press

Book Chapters

O’Brien E, Turner JR, Karnard DK, Kothari S. Blood Pressure Responses to Noncardiovascular Drugs. In: Cardiovascular safety in drug development and therapeutic use: new methodologies and evolving regulatory landscapes. Eds: Turner JR, Karnad DR, Kothari S.  Springer International Publishing Switzerland.2017. Pp 223-238.

Atkins N, O’Brien E. Validation and Reliability Testing of Bloodn Pressure Monitors. In: Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. 3rd Edition. Ed. William B. White. Humana Press. 2016. Pp. 77-101.

Booklets

O’Brien E. Essays Towards Improving Blood Pressure Management. Irish Medical Times Supplement. May 2015. Pp.20

General and Educational

O’Brien E, Dolan E. The sorry state of BP control in Ireland. Irish Medical Times 2016; 03.25.p.24

O’Brien E. Changes in the management of hypertension. Irish Medical Times 2016; January

O’Brien E. High Blood Pressure: the largest epidemic known to mankind. Irish Times 2016;07.19

Dolan E, O’Brien E. How should ABPM be used in general practice? Irish Medical Times 28.11.2016.p.32-33

Dolan E, O’Brien E. How should ABPM be used in general practice? Irish Medical Times: Clinical Times 2016/2017 Annual p.22-26

O’Brien E. Literature and medicine; towards being a good doctor.Hypertension News. 2016

O’Brien E. Mathmatician who was simply No.!. Review of The Bold Collegian: Treveor West. Sunday Times. 06.11.2016

O’Brien E. Now I see the true value of nurses. Sunday Times. 04.12.2016.p.19

O’Brien E. Single pill combinations: an underestimated advance. Irish Medical Times 09.12.2016.p.26